Genome-wide hydroxymethylcytosine pattern changes in response to oxidative stress
| Data(s) |
01/08/2015
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|---|---|
| Resumo |
The TET enzymes convert methylcytosine to the newly discovered base hydroxymethylcytosine. While recent reports suggest that TETs may play a role in response to oxidative stress, this role remains uncertain, and results lack in vivo models. Here we show a global decrease of hydroxymethylcytosine in cells treated with buthionine sulfoximine, and in mice depleted for the major antioxidant enzymes GPx1 and 2. Furthermore, genome-wide profiling revealed differentially hydroxymethylated regions in coding genes, and intriguingly in microRNA genes, both involved in response to oxidative stress. These results thus suggest a profound effect of in vivo oxidative stress on the global hydroxymethylome. SCOPUS: ar.j info:eu-repo/semantics/published |
| Formato |
1 full-text file(s): application/pdf |
| Identificador |
uri/info:doi/10.1038/srep12714 uri/info:pii/srep12714 uri/info:pmid/26239807 https://dipot.ulb.ac.be/dspace/bitstream/2013/218113/1/PMC4523844.pdf http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/218113 |
| Idioma(s) |
en |
| Direitos |
1 full-text file(s): info:eu-repo/semantics/closedAccess |
| Fonte |
Scientific reports, 5 |
| Palavras-Chave | #Phénomènes atmosphériques |
| Tipo |
info:eu-repo/semantics/article info:ulb-repo/semantics/articlePeerReview info:ulb-repo/semantics/openurl/article |
