Cytokine and antibody profiles in 1-year-old children vaccinated with either acellular or whole-cell pertussis vaccine during infancy.
Data(s) |
01/10/2009
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Resumo |
Two different types of pertussis vaccines are currently available to protect children against whooping cough, the first-generation whole-cell (Pw) vaccines and the more recent acellular (Pa) vaccines. Both types provide good protection, yet induce different types of immune responses in 6-month-old infants, with a strong Th1 response induced by Pw vaccines compared to a mixed Th1/Th2 response and a delay in non-specific IFN-gamma secretions after the administration of Pa vaccines. We show here that at 13 months of age, most Pw- or Pa-vaccinated children display Bordetella pertussis-specific T-cell responses, in addition to significant antibody levels, although a higher Th2/Th1 cytokine ratio remained in Pa recipients compared to Pw recipients. In contrast, the proportion of children with tetanus toxin-specific T-cell responses was lower in Pa than in Pw vaccine recipients, although most children had protective anti-tetanus toxin IgG levels. In addition, the global Th2 bias observed in 6-month-old infants vaccinated with a Pa vaccine was normalized at 13 months. Journal Article Research Support, Non-U.S. Gov't info:eu-repo/semantics/published |
Formato |
1 full-text file(s): application/pdf |
Identificador |
uri/info:doi/10.1016/j.vaccine.2009.07.075 uri/info:pii/S0264-410X(09)01109-8 uri/info:pmid/19665604 https://dipot.ulb.ac.be/dspace/bitstream/2013/153396/1/Elsevier_138009.pdf http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/153396 |
Idioma(s) |
en |
Direitos |
1 full-text file(s): info:eu-repo/semantics/restrictedAccess |
Fonte |
Vaccine, 27 (43 |
Palavras-Chave | #Immunologie #Antibodies, Bacterial -- blood -- immunology #Cells, Cultured #Cytokines -- blood -- immunology #Follow-Up Studies #Humans #Immunity, Cellular #Immunoglobulin G -- blood -- immunology #Infant #Leukocytes, Mononuclear -- immunology #Pertussis Vaccine -- immunology #Tetanus Toxoid -- immunology #Th1 Cells -- immunology #Th2 Cells -- immunology #Vaccines, Acellular -- immunology #Whooping Cough -- immunology -- prevention & control |
Tipo |
info:eu-repo/semantics/article info:ulb-repo/semantics/articlePeerReview info:ulb-repo/semantics/openurl/article |