Monocyte-derived interleukin-10 depresses the Bordetella pertussis- specific gamma interferon response in vaccinated infants.
| Data(s) |
01/12/2009
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|---|---|
| Resumo |
Antigen-specific gamma interferon (IFN-gamma) has been demonstrated to participate in protection against Bordetella pertussis infection. Circulating mononuclear cells from B. pertussis-infected and from pertussis-vaccinated infants secrete high amounts of IFN-gamma after in vitro stimulation by B. pertussis antigens, but with a large variation in the secreted IFN-gamma levels between individuals. We show here that the inhibition of the specific IFN-gamma response can be at least partially attributed to IL-10 secretion by monocytes. This IL-10 secretion was not associated with polymorphisms at positions -1082, -819, and -592 of the IL-10 gene promoter, suggesting that other genetic or environmental factors affect IL-10 expression and secretion. Journal Article Research Support, Non-U.S. Gov't info:eu-repo/semantics/published |
| Formato |
No full-text files |
| Identificador |
uri/info:doi/10.1128/CVI.00314-09 uri/info:pii/CVI.00314-09 uri/info:pmid/19846681 http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51088 |
| Idioma(s) |
en |
| Fonte |
Clinical and vaccine immunology, 16 (12 |
| Palavras-Chave | #Sciences bio-médicales et agricoles #Adhesins, Bacterial -- pharmacology #Alleles #Antibodies, Monoclonal -- pharmacology #Bordetella pertussis -- immunology #Genotype #Humans #Immunologic Factors -- pharmacology #Infant #Interferon-gamma -- agonists #Interferon-gamma -- biosynthesis #Interferon-gamma -- immunology #Interleukin-10 -- antagonists & inhibitors #Interleukin-10 -- biosynthesis #Interleukin-10 -- genetics #Interleukin-10 -- immunology #Interleukin-12 -- agonists #Interleukin-12 -- biosynthesis #Interleukin-12 -- immunology #Leukocytes, Mononuclear -- drug effects #Leukocytes, Mononuclear -- immunology #Leukocytes, Mononuclear -- metabolism #Leukocytes, Mononuclear -- microbiology #Longitudinal Studies #Pertussis Toxin -- pharmacology #Pertussis Vaccine -- immunology #Polymorphism, Genetic -- genetics #Polymorphism, Genetic -- immunology #Virulence Factors, Bordetella -- pharmacology #Whooping Cough -- immunology #Whooping Cough -- microbiology #Whooping Cough -- prevention & control |
| Tipo |
info:eu-repo/semantics/article info:ulb-repo/semantics/articlePeerReview info:ulb-repo/semantics/openurl/article |
