Cellular immune responses of preterm infants after vaccination with whole-cell or acellular pertussis vaccines.
Data(s) |
01/02/2010
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Resumo |
Based on studies reporting specific antibody titers, it is recommended to vaccinate preterm infants against Bordetella pertussis according to their chronological age. However, as specific T-cell responses also are involved in the protection against B. pertussis, we have determined whether highly preterm infants (<31 weeks) are able to mount these immune responses during vaccination. Forty-eight premature infants were vaccinated at 2, 3, and 4 months of their chronological age with an acellular (Pa; n = 24) or a whole-cell (Pw; n = 24) tetravalent diphtheria-tetanus-pertussis-polio vaccine, and blood samples were collected at 2, 3, and 6 months of age. Most of the Pa- and Pw-vaccinated infants developed at 3 or 6 months of age a gamma interferon (IFN-gamma) response to the B. pertussis antigens, accompanied by an interleukin-5 (IL-5) and IL-13 secretion for the Pa-vaccinated infants. No association was found between a very low infant birth weight, the occurrence of severe infections, and corticosteroid treatment or the administration of gammaglobulins with a low level of antigen-induced IFN-gamma secretion. We conclude that like full-term infants, most preterm infants are able to mount a specific cellular immune response to the administration of the first doses of an acellular or a whole-cell pertussis vaccine. Journal Article Research Support, Non-U.S. Gov't info:eu-repo/semantics/published |
Formato |
No full-text files |
Identificador |
uri/info:doi/10.1128/CVI.00328-09 uri/info:pii/CVI.00328-09 uri/info:pmid/20016042 http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51090 |
Idioma(s) |
en |
Fonte |
Clinical and vaccine immunology, 17 (2 |
Palavras-Chave | #Sciences bio-médicales et agricoles |
Tipo |
info:eu-repo/semantics/article info:ulb-repo/semantics/articlePeerReview info:ulb-repo/semantics/openurl/article |