The Ets transcription factors of the PEA3 group: Transcriptional regulators in metastasis
| Data(s) |
01/08/2006
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|---|---|
| Resumo |
The PEA3 group is composed of three highly conserved Ets transcription factors: Erm, Er81, and Pea3. These proteins regulate transcription of multiple genes, and their transactivating potential is affected by post-translational modifications. Among their target genes are several matrix metalloproteases (MMPs), which are enzymes degrading the extracellular matrix during normal remodelling events and cancer metastasis. In fact, PEA3-group genes are often over-expressed in different types of cancers that also over-express these MMPs and display a disseminating phenotype. Experimental regulation of the synthesis of PEA3 group members influences the metastatic process. This suggests that these factors play a key role in metastasis. © 2006 Elsevier B.V. All rights reserved. SCOPUS: re.j info:eu-repo/semantics/published |
| Formato |
1 full-text file(s): application/pdf |
| Identificador |
uri/info:doi/10.1016/j.bbcan.2006.02.002 uri/info:pii/S0304419X06000084 uri/info:pmid/16546322 https://dipot.ulb.ac.be/dspace/bitstream/2013/171140/1/Elsevier_154770.pdf http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/171140 |
| Idioma(s) |
en |
| Direitos |
1 full-text file(s): info:eu-repo/semantics/restrictedAccess |
| Fonte |
Biochimica et biophysica acta, CR. Reviews on cancer, 1766 (1 |
| Palavras-Chave | #Cancérologie #Biologie #Ets #Metastasis #MMP #PEA3 group #Transcription factor |
| Tipo |
info:eu-repo/semantics/article info:ulb-repo/semantics/articlePeerReview info:ulb-repo/semantics/openurl/article |
