Herbal Dietary Supplements: Safety, Efficacy, and Use by Breast Cancer Survivors


Autoria(s): Frechette, Peter; Galanie, Stephanie; Hung, Anna; Kim, Sarah; Merrick, Kelsey; Nataraj, Krupa; Nooralian, Jessica; Patel, Mihir; Stevens, Jessica; Wang, Vivian; Zhou, Albert
Contribuinte(s)

Kantor, Mark K.

Data(s)

26/05/2010

26/05/2010

2010

Resumo

Gemstone Team IMAC (Integrative Medicine and Cancer)

Herbal dietary supplements (HDS) are widely used in complementary, alternative, and integrative medicine, but data on attitudes, behavior, safety, and efficacy are lacking. Using mixed methods, we administered an online survey to >1,000 breast cancer survivors to investigate HDS practices and perceptions and performed in vitro studies assessing the efficacy and toxicity of actein, a bioactive component of the HDS black cohosh (Actaea racemosa). Among cancer survivors, curcumin, flaxseed, and green tea were reported as the most frequently used HDS. Many subjects increased HDS intake after diagnosis and sought web-based information on HDS. In human breast cancer (MCF-7) and liver (HepG2/C3A) cell lines, actein had anti-proliferative and anti-estrogenic effects and did not exhibit hepatotoxicity or affect the action of tamoxifen and raloxifene.

Identificador

http://hdl.handle.net/1903/10088

Idioma(s)

en_US

Relação

Digital Repository at the University of Maryland

Gemstone Program, University of Maryland (College Park, Md)

Palavras-Chave #Herbal dietary supplements #Medicine #Breast cancer #Gemstone Team IMAC (Integrative Medicine and Cancer)
Tipo

Thesis