Reductive ligation mediated one-step disulfide formation of S-nitrosothiols.
| Data(s) |
17/09/2010
|
|---|---|
| Formato |
4208 - 4211 |
| Identificador |
http://www.ncbi.nlm.nih.gov/pubmed/20731371 Org Lett, 2010, 12 (18), pp. 4208 - 4211 http://hdl.handle.net/10161/4108 1523-7052 |
| Idioma(s) |
ENG en_US |
| Relação |
Org Lett 10.1021/ol101863s Organic letters |
| Tipo |
Journal Article |
| Cobertura |
United States |
| Resumo |
A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, which then undergo a fast intermolecular disulfide formation to form stable conjugates. This reaction can be used to design new biosensors of S-nitrosated proteins. |
| Palavras-Chave | #Disulfides #Molecular Structure #Oxidation-Reduction #Phosphines #S-Nitrosothiols |
