Anti-cholinergic load, health care utilization, and survival in people with advanced cancer: a pilot study.
Cobertura |
United States |
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Data(s) |
01/06/2010
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Resumo |
INTRODUCTION: Anti-cholinergic medications have been associated with increased risks of cognitive impairment, premature mortality and increased risk of hospitalisation. Anti-cholinergic load associated with medication increases as death approaches in those with advanced cancer, yet little is known about associated adverse outcomes in this setting. METHODS: A substudy of 112 participants in a randomised control trial who had cancer and an Australia modified Karnofsky Performance Scale (AKPS) score (AKPS) of 60 or above, explored survival and health service utilisation; with anti-cholinergic load calculated using the Clinician Rated Anti-cholinergic Scale (modified version) longitudinally to death. A standardised starting point for prospectively calculating survival was an AKPS of 60 or above. RESULTS: Baseline entry to the sub-study was a mean 62 +/- 81 days (median 37, range 1-588) days before death (survival), with mean of 4.8 (median 3, SD 4.18, range 1 - 24) study assessments in this time period. Participants spent 22% of time as an inpatient. There was no significant association between anti-cholinergic score and time spent as an inpatient (adjusted for survival time) (p = 0.94); or survival time. DISCUSSION: No association between anti-cholinergic load and survival or time spent as an inpatient was seen. Future studies need to include cognitively impaired populations where the risks of symptomatic deterioration may be more substantial. |
Formato |
745 - 752 |
Identificador |
http://www.ncbi.nlm.nih.gov/pubmed/20597708 J Palliat Med, 2010, 13 (6), pp. 745 - 752 http://hdl.handle.net/10161/3311 1557-7740 |
Idioma(s) |
ENG en_US |
Relação |
J Palliat Med 10.1089/jpm.2009.0365 Journal of palliative medicine |
Palavras-Chave | #Aged #Aged, 80 and over #Australia #Cholinergic Antagonists #Dose-Response Relationship, Drug #Female #Health Services #Humans #Karnofsky Performance Status #Male #Middle Aged #Neoplasm Staging #Neoplasms #Pilot Projects #Survival Analysis |
Tipo |
Journal Article |