Equal IgG antibody response to pneumococcal vaccination in all stages of human immunodeficiency virus disease.


Autoria(s): Vandenbruaene, M.; Colebunders, R; Mascart, Françoise; Haerden, Y; Van Hove, D; Peeters, Martine; Goeman, J; Van Royen, P; Avonts, D
Data(s)

01/08/1995

Resumo

To evaluate the immunogenicity and safety of a 23-valent pneumococcal vaccine in human immunodeficiency virus (HIV)-seropositive patients, 80 men and 18 women received 1 dose of the vaccine (Pneumo 23; Pasteur Mérieux MSD, Brussels). The total IgG antibody response against all 23 Streptococcus pneumoniae capsular antigens was measured. Antibody levels were expressed in arbitrary units per microliter, referring to a standard curve. Geometric mean titers of the total IgG capsular antibodies on the day of vaccination and 30-45 days later were compared. The ratios of titers after and before vaccination in patients with > 500, 200-500, and < 200 CD4 lymphocytes/microL were 10, 10, and 12.6, respectively. Nonresponse (ratio < 4) occurred in 17% of patients and was unrelated to CD4 cell count. The vaccine was well tolerated; no serious side effects occurred. In 83% of the patients with HIV infection, the total antipneumococcal IgG level was higher after vaccination.

Journal Article

info:eu-repo/semantics/published

Formato

No full-text files

Identificador

uri/info:pmid/7622903

http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/143803

Idioma(s)

en

Fonte

The Journal of infectious diseases, 172 (2

Palavras-Chave #Immunologie #Pneumologie #Adult #Antibody Formation #Bacterial Vaccines -- immunology #CD4 Lymphocyte Count #Female #HIV Infections -- immunology #HIV Seropositivity -- immunology #Humans #Immunoglobulin G -- blood #Male #Pneumococcal Vaccines #Streptococcus pneumoniae -- immunology
Tipo

info:eu-repo/semantics/article

info:ulb-repo/semantics/articlePeerReview

info:ulb-repo/semantics/openurl/article