Optimal assessment of the ability of children with recurrent respiratory tract infections to produce anti-polysaccharide antibodies.
Data(s) |
01/08/2007
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Resumo |
Specific anti-polysaccharide antibody deficiency (SPAD) is an immune disorder. Diagnostic criteria have not yet been defined clearly. One hundred and seventy-six children evaluated for recurrent respiratory tract infections were analysed retrospectively. For each subject, specific anti-pneumococcal antibodies had been measured with two enzyme-linked immunosorbent assays (ELISAs), one overall assay (OA) using the 23-valent pneumococcal polysaccharide vaccine (23-PPSV) as detecting antigen and the other purified pneumococcal polysaccharide serotypes (serotype-specific assay, SSA) (serotypes 14, 19F and 23F). Antibody levels were measured before (n = 176) and after (n = 93) immunization with the 23-PPSV. Before immunization, low titres were found for 138 of 176 patients (78%) with OA, compared to 20 of 176 patients (11%) with the SSA. We found a significant correlation between OA and SSA results. After immunization, 88% (71 of 81) of the patients considered as responders in the OA test were also responders in the SSA; 93% (71 of 76) of the patients classified as responders according to the SSA were also responders in the OA. SPAD was diagnosed in 8% (seven of 93) of patients on the basis of the absence of response in both tests. Thus, we propose to use OA as a screening test for SPAD before 23-PPSV immunization. After immunization, SSA should be used only in case of a low response in OA. Only the absence of or a very low antibody response detected by both tests should be used as a diagnostic criterion for SPAD. Journal Article Multicenter Study info:eu-repo/semantics/published |
Formato |
1 full-text file(s): application/pdf |
Identificador |
uri/info:doi/10.1111/j.1365-2249.2007.03409.x uri/info:pii/CEI3409 uri/info:pmid/17511778 uri/info:pmcid/PMC1941946 https://dipot.ulb.ac.be/dspace/bitstream/2013/51075/1/PMC1941946.pdf http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51075 |
Idioma(s) |
en |
Direitos |
1 full-text file(s): info:eu-repo/semantics/closedAccess |
Fonte |
Clinical and experimental immunology, 149 (2 |
Palavras-Chave | #Sciences bio-médicales et agricoles #Adolescent #Aging -- immunology #Antibodies, Bacterial -- biosynthesis #Antibodies, Bacterial -- blood #Child #Child, Preschool #Follow-Up Studies #Humans #Immunization #Immunoglobulin A -- blood #Immunoglobulin G -- blood #Immunologic Deficiency Syndromes -- diagnosis #Immunologic Deficiency Syndromes -- immunology #Infant #Pneumococcal Vaccines -- immunology #Polysaccharides, Bacterial -- immunology #Recurrence #Respiratory Tract Infections -- immunology #Retrospective Studies #Anti-pneumococcal antibody #Anti-polysaccharide antibody #Pneumococcal polysaccharide vaccine #Respiratory tract infection |
Tipo |
info:eu-repo/semantics/article info:ulb-repo/semantics/articlePeerReview info:ulb-repo/semantics/openurl/article |