The effects of ageing and exercise on skeletal muscle structure and function
Contribuinte(s) |
Abertay University. School of Social & Health Sciences |
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Data(s) |
19/04/2016
19/04/2016
01/04/2016
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Resumo |
Musculoskeletal ageing is associated with profound morphological and functional changes that increase fall risk and disease incidence and is characterised by age-related reductions in motor unit number and atrophy of muscle fibres, particularly type II fibres. Decrements in functional strength and power are relatively modest until the 6th decade, after which the rate of loss exponentially accelerates, particularly beyond the 8th decade of life. Physical activity is a therapeutic modality that can significantly attenuate age-related decline. The underlying signature of ageing, as manifested by perturbed redox homeostasis, leads to a blunting of acute and chronic redox regulated exercise adaptations. Impaired redox regulated exercise adaptations are mechanistically related to altered exercise-induced reactive oxygen and nitrogen species generation and a resultant failure to properly activate redox regulated signaling cascades. Despite the aforementioned specific impairment in redox signaling, exercise induces a plethora of beneficial effects, irrespective of age. There is, therefore, strong evidence for promoting regular physical exercise, especially progressive resistance training as a lifelong habitual practice. |
Identificador |
Malone, J. 2016. The effects of ageing and exercise on skeletal muscle structure and function. In: A. Alkhatib. ed. Sedentary lifestyle: Predictive factors, health risks and physiological implications. New York: Nova Science Publishers. pp.69-84. 978-1-63484-673-8 |
Idioma(s) |
en |
Publicador |
Nova Science Publishers |
Relação |
Sedentary lifestyle: predictive factors, health risks and physiological implications. |
Direitos |
This is the author's version of a chapter published in Sedentary Lifestyle: Predictive Factors, Health Risks and Physiological Implications, edited by A. Alkhatib © 2016 Nova Science Publishers |
Palavras-Chave | #Sarcopenia #Atrophy #Reduced function #Redox signalling #Exercise interventions |
Tipo |
Book chapter published n/a accepted |