Exercise training can induce cardiac autophagy at end-stage chronic conditions: Insights from a graft-versus-host-disease mouse model


Autoria(s): Fiuza Luces, María del Carmen; Delmiro, Aitor; Soares-Miranda, Luisa; González-Murillo, África; Martínez Palacio, Jesús; Lucía Mulas, Alejandro; Morán, María
Data(s)

11/04/2014

11/04/2014

2014

Resumo

Chronic graft-versus-host disease (cGVHD) is a frequent cause of morbimortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and severely compromises patients' physical capacity. Despite the aggressive nature of the disease, aerobic exercise training can positively impact survival as well as clinical and functional parameters. We analyzed potential mechanisms underlying the recently reported cardiac function improvement in an exercise-trained cGVHD murine model receiving lethal total body irradiation and immunosuppressant treatment (Fiuza-Luces et al., 2013. Med Sci Sports Exerc 45, 1703-1711). We hypothesized that a cellular quality-control mechanism that is receiving growing attention in biomedicine, autophagy, was involved in such improvement. Our results suggest that exercise training elicits a positive autophagic adaptation in the myocardium that may help preserve cardiac function even at the end-stage of a devastating disease like cGVHD. These preliminary findings might provide new insights into the cardiac exercise benefits in chronic/debilitating conditions.

Proyecto PI12/00914 (Fondo de Investigaciones Sanitarias)

5.889 JCR (2014) Q1, 20/148 Immunology, 27/252 Neurosciences

UEM

Identificador

Fiuza-Luces, C., Delmiro, A., Soares-Miranda, L., González-Murillo, A., Martínez-Palacio, J., & Lucía-Mulas, A. (2014). Exercise training can induce cardiac autophagy at end-stage chronic conditions: insights from a graft-versus-host-disease mouse model. Brain, Behavior, and Immunity (in press). http://dx.doi.org/10.1016/j.bbi.2013.11.007.

08891591

http://hdl.handle.net/11268/2755

10.1016/j.bbi.2013.11.007

Idioma(s)

eng

Direitos

restrictedAccess

Palavras-Chave #Deportes - Entrenamiento #Ciencias médicas
Tipo

article