Reviews on The Immunological Function of Tetraspanins


Autoria(s): Gui Lang; Wang Bing; Li Fu-Hua; Xiang Jian-Hai
Data(s)

01/11/2008

Resumo

Tetraspanins belongs to the transmembrane 4 superfamily(TM4SF). They can be as a bridge to connect the proteins outside or inside the cell membrane. A tetraspanins web is formed by the tetraspnins-proteins complex, and the web is believed to involve in fundamental functions of immunity system, and consequnently, signaling between cells and inside cells, regulating cell activation and adhesion, participating in the identification and infection of some virus. As a family of conservative transmembrane proteins, tetraspanins play multiplex roles in invertebrate. It was described how tetraspanin microdomains might have functions in the immune system, and how they contact with virus. In addition, the important role of tetraspanins in the innate immune system of invertebrate were discussed.

Tetraspanins belongs to the transmembrane 4 superfamily(TM4SF). They can be as a bridge to connect the proteins outside or inside the cell membrane. A tetraspanins web is formed by the tetraspnins-proteins complex, and the web is believed to involve in fundamental functions of immunity system, and consequnently, signaling between cells and inside cells, regulating cell activation and adhesion, participating in the identification and infection of some virus. As a family of conservative transmembrane proteins, tetraspanins play multiplex roles in invertebrate. It was described how tetraspanin microdomains might have functions in the immune system, and how they contact with virus. In addition, the important role of tetraspanins in the innate immune system of invertebrate were discussed.

Identificador

http://ir.qdio.ac.cn/handle/337002/5565

http://www.irgrid.ac.cn/handle/1471x/166385

Idioma(s)

英语

Fonte

Gui Lang; Wang Bing; Li Fu-Hua; Xiang Jian-Hai.Reviews on The Immunological Function of Tetraspanins,PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2008,35(11):1231-1238

Palavras-Chave #Biochemistry & Molecular Biology; Biophysics #tetraspanins #immunity #virus #transmembrane 4 superfamily #invertebrate
Tipo

期刊论文