Studies of Gd-diethylenetriamine pentaacetic acid in boving serum albumin solution by nuclear magnetic resonance spectroscopy


Autoria(s): Li XJ; Feng JH; Li XY; Wu YJ; Pei FK
Data(s)

2000

Resumo

In this paper, the water relaxation enhancement behavior of Gd-diethylenetriamine pentaacetic acid(DTPA) in water and in aqueous solution of bovine serum albumine(BSA) has been studied. The T-1 relaxivity of Gd-DTPA in BSA solution is higher than that in aqueous solution. The results indicate that Gd-DTPA can integrate non-covalently with BSA mainly in forms of (Gd-DTPA) . BSA, (Gd-DTPA)(2) . BSA, for which the apparent equilibrium constant is 0.026 mmol(-1).L,0.0018 mmol(-2).L-2 respectively. This method would be used to study the interactivities between protein and contrast agent.

Identificador

http://202.98.16.49/handle/322003/19813

http://www.irgrid.ac.cn/handle/1471x/154641

Idioma(s)

中文

Fonte

Li XJ;Feng JH;Li XY;Wu YJ;Pei FK.Studies of Gd-diethylenetriamine pentaacetic acid in boving serum albumin solution by nuclear magnetic resonance spectroscopy,CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2000,28(3):269-272

Palavras-Chave #PROTON RELAXATION #GADOLINIUM(III) #COMPLEXES #DTPA #AGENTS
Tipo

期刊论文