Comparison of biochemical effects induced by Changle between male and female rats using NMR and ICP-MS techniques
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2006
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Resumo |
Metabolic profiles caused by rare earth complex were investigated using NMR and ICP-MS techniques. Male and female Wistar rats were treated orally with Changle (A kind of rare earth complex applied in agriculture to raise the production of crops) at dose of 2, 5 and 20 mg (.) kg(-1) body weight/day respectively for 90 d. Urine and serum samples are collected on 90 d. The relative concentrations of important endogenous metabolites in urine and serum are determined from H-1 NMR spectra and the contents of the four rare earth elements ( La, Ce, Pr and Nd) constituting Changle in the serum samples are measured by ICP-MS technique. Changle-induced renal and liver damage in rats is found based on the increase in the amounts of the amino acids, trimethylamine N-oxide, N, N-dimethyglycine, dimethylamine, succinate, aketoglutarate and ethanol as well as rare earth concentrations. The similarities and differentiations are found in the alteration patterns of metabolites and rare earth concentrations in serum. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Wu HF;Li XJ;Feng JH;Li WS;Li ZF;Liao PQ;Wu YJ;Pei FK.Comparison of biochemical effects induced by Changle between male and female rats using NMR and ICP-MS techniques,JOURNAL OF RARE EARTHS,2006,24(1):108-114 |
Palavras-Chave | #MAGNETIC-RESONANCE SPECTROSCOPY #PATTERN-RECOGNITION METHODS #H-1-NMR SPECTROSCOPY #URINE #CLASSIFICATION #METABOLITES #IDENTIFICATION #NEPHROTOXICITY #SPECTRA #LESIONS |
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期刊论文 |