Analysis of strychnos alkaloids using electrospray ionization Fourier transform ion cyclotron resonance multi-stage tandem mass spectrometry


Autoria(s): Yan J; Liu ZQ; Yan CY; Xing JP; Liu SY
Data(s)

2006

Resumo

The fragmentations of four strychnos alkaloids have been investigated by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS) in the positive ion mode. Experiments using multi-stage tandem mass spectrometry (ESI-FT-ICR-MSn) allowed us to obtain precise elemental compositions of product ions at high mass resolution. The experimental data demonstrated that the nitrogen bridge and the coordinated oxygen atom on the nitrogen bridge in the alkaloid compounds were the active sites in the MS2 fragmentations. The loss of CH3 or the OCH3 group in those alkaloids, which have an OCH3 substituent, was the dominant fragmentation mode in the MS3 fragmentations. Logical fragmentation schemes for strychnos alkaloids have been proposed and these should be useful for the identification of these compounds.

Identificador

http://ir.ciac.jl.cn/handle/322003/16141

http://www.irgrid.ac.cn/handle/1471x/151857

Idioma(s)

英语

Fonte

Yan J;Liu ZQ;Yan CY;Xing JP;Liu SY.Analysis of strychnos alkaloids using electrospray ionization Fourier transform ion cyclotron resonance multi-stage tandem mass spectrometry,RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2006,20(8):1335-1344

Palavras-Chave #CINCHONA ALKALOIDS #IDENTIFICATION #ELUCIDATION #SEPARATION #SPECTRA #SAMPLES
Tipo

期刊论文