Reagent-controlled asymmetric iodolactonization using cinchona alkaloids as chiral sources


Autoria(s): Wang M; Gao LX; Yue W; Mai WP
Data(s)

2004

Resumo

A novel method for reagent-controlled asymmetric iodolactonization of 5-aryl-4-pentenoic acids is reported. This work uses carboxylate ion pairs combined with cinchona alkaloids as chiral sources of carboxylate anion for the first time leading to a mixture of two regio-isomeric iodolactones with moderate enantioselectivity (exo- 18.5% ee, endo-35.0% ee) under mild reaction conditions.

Identificador

http://ir.ciac.jl.cn/handle/322003/15151

http://www.irgrid.ac.cn/handle/1471x/150900

Idioma(s)

英语

Fonte

Wang M;Gao LX;Yue W;Mai WP.Reagent-controlled asymmetric iodolactonization using cinchona alkaloids as chiral sources,SYNTHETIC COMMUNICATIONS,2004,34(6 ):1023-1032

Palavras-Chave #AUXILIARY #3 #5-DISUBSTITUTED-GAMMA-BUTYROLACTONES #HALOCYCLIZATION #AMIDES
Tipo

期刊论文