Preparation of nano-hydroxyapatite/poly(L-lactide) biocomposite microspheres
Data(s) |
2007
|
---|---|
Resumo |
Nano-hydroxyapatite (HA)/poly(L-lactide) (PLLA) composite microspheres with relatively uniform size distribution were prepared by a solid-in-oil-in-water (s/o/w) emusion solvent evaporation method. The encapsulation of the HA nanopaticles in microshperes was significantly improved by grafting PLLA on the surface of the HA nanoparticles (p-HA) during emulsion process. This procedure gave a possibility to obtain p-HA/PLLA composite microspheres with uniform morphology and the encapsulated p-HA nanoparticle loading reached up to 40 wt% (33 wt% of pure HA) in the p-HA/PLLA composite microspheres. The microstructure of composite microspheres from core-shell to single phase changed with the variation of p-HA to PLLA ratios. p-HA/PLLA composite microspheres with the diameter range of 2-3 mu m were obtained. The entrapment efficiency of p-HA in microspheres could high up to 90 wt% and that of HA was only 13 wt%. Surface and bulk characterizations of the composite microspheres were performed by measurements such as wide angle X-ray diffraction (WAXD), thermal gravimetric analysis (TGA), environmental scanning electron microscope (ESEM) and transmission electron microscopy (TEM). |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Qiu XY;Han YD;Zhuang XL;Chen XS;Li YS;Jing XB.Preparation of nano-hydroxyapatite/poly(L-lactide) biocomposite microspheres,JOURNAL OF NANOPARTICLE RESEARCH,2007 ,9(5):901-908 |
Palavras-Chave | #COMPOSITE MICROSPHERES #POLYMER MICROSPHERES #HYDROXYAPATITE #ENCAPSULATION #PARTICLES #SHELLS |
Tipo |
期刊论文 |