Physical and spectral characterization of the human cyclin A gene and its interactions with anthracycline anticancer drugs
Data(s) |
2007
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Resumo |
Over expression of cyclin A in human tumors has been linked to cancer by various experimental lines of evidence. However, physical and spectral characterization of the human cyclin A gene and its interactions with anticancer drugs have not been reported. Our gene sequence analysis, singular value decomposition method and melting studies in the presence of antitumor agents, daunomycin, doxorubicin and Hoechst 33258 showed that cyclin A gene had both AT-rich and GC-rich domains. For a ligand with unknown DNA binding specificity, this gene sequence can be used to differentiate its DNA binding preference. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Bao HX;Wang XH;Yu HJ;Fu ML;Qu XG;Zheng YC;Ren JS.Physical and spectral characterization of the human cyclin A gene and its interactions with anthracycline anticancer drugs,CHEMICAL PHYSICS LETTERS ,2007 ,436(1-3):252-257 |
Palavras-Chave | #DEPENDENT KINASE-2 #ACID COMPLEX #DNA-BINDING #CELL-CYCLE #EXPRESSION #CANCER #OVEREXPRESSION #TRANSCRIPTION #INHIBITION #TRANSITION |
Tipo |
期刊论文 |