Photoinduced DNA Cleavage by alpha-, beta-, and gamma-Cyclodextrin-Bicapped C-60 Supramolecular Complexes


Autoria(s): Wang DY; Sun LL; Liu W; Chang WW; Gao X; Wang ZX
Data(s)

2009

Resumo

Water-soluble supramolecular inclusion complexes of alpha-, beta-, and gamma-cyclodextrin-bicapped C-60 (CD/C-60) have been investigated for their photoinduced DNA cleavage activities, with the aim to assess the potential health risks of this class of compounds and to understand the effect of host cyclodextrins having different cavity dimensions. Factors such as incubation temperature, irradiation time, and concentration of NADH or CDs/C-60 supramolecular inclusion complexes have been examined. The results show that alpha-, beta-, and gamma-CDs/C-60 are all able to cleave double-stranded DNA under visible light irradiation in the presence of NADH. However, a difference in the photoinduced DNA cleavage efficiency is observed, where the cleavage efficiency increases in the order of alpha-, beta-, and gamma-CD/C-60. The difference is attributed to the different aggregation behavior of the inclusion complexes in aqueous solution, which is correlated to the cavity dimension of the host cyclodextrin molecules.

Identificador

http://202.98.16.49/handle/322003/12657

http://www.irgrid.ac.cn/handle/1471x/148741

Idioma(s)

英语

Fonte

Wang DY;Sun LL;Liu W;Chang WW;Gao X;Wang ZX.Photoinduced DNA Cleavage by alpha-, beta-, and gamma-Cyclodextrin-Bicapped C-60 Supramolecular Complexes,ENVIRONMENTAL SCIENCE & TECHNOLOGY,2009,43(15):5825-5829

Palavras-Chave #FULLERENE WATER SUSPENSION #CARBON-BASED NANOMATERIALS #AQUEOUS-SOLUTION #PHOTOPHYSICAL PROPERTIES #NANOSCALE AGGREGATION #SOLUBLE FULLERENE #INCLUSION COMPLEX #ELECTRON-TRANSFER #CENTER-DOT #DERIVATIVES
Tipo

期刊论文