Synthesis and self-assembly of a novel Y-shaped copolymer with a helical polypeptide arm
Data(s) |
2009
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Resumo |
novel biodegradable Y-shaped copolymer, poly(L-lactide)(2)-b-poly(gamma-benzyl-L-glutamic acid) (PLLA(2)-b-PBLG), was synthesized by the ring-opening polymerization (ROP) of N-carboxyanhydride of gamma-benzyl-L-glutamate (BLG-NCA) with centrally amino-functionalized poly(L-lactide), PLLA(2)-NH2, as a macroinitiator in a convenient way. The Y-shaped copolymer and its precursors were characterized by H-1 NMR, FT-IR, GPC, WAXD and DSC measurements. The self-assembly of the PLLA(2)-b-PBLG copolymer in toluene and benzyl alcohol was examined. It was found that the self-assembly of the copolymer was dependent on solvent and on relative length of the PBLG block. For a copolymer with PLLA blocks of 26 in total degree of polymerization (DP), if the PBLG block was long enough (e.g., DP = 54 or more), the copolymer/toluene solution became a transparent gel at room temperature. In benzyl alcohol Solution, only PLLA(2)-b-PBLG containing ca. 190 BLG residues could form a gel: those with shorter PBLG blocks (e.g., DP = 54) became nano-scale fibrous aggregates and these aggregates were dispersed in benzyl alcohol homogeneously. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Sun J;Chen XS;Guo JS;Shi Q;Xie ZG;Jing XB.Synthesis and self-assembly of a novel Y-shaped copolymer with a helical polypeptide arm,POLYMER,2009,50(2):455-461 |
Palavras-Chave | #N-CARBOXYANHYDRIDES #BLOCK-COPOLYMERS #TRIBLOCK COPOLYMERS #DIBLOCK COPOLYMERS #POLYMERIZATION #NANOFIBERS #PEPTIDE #SUPERSTRUCTURES #ACID) #PH |
Tipo |
期刊论文 |