Surface-Relevant Regulable DNA Toroids Induced by Dopamine
Data(s) |
2009
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Resumo |
Dopamine (2-(3,4-dihydroxyphenyl)ethylamine) is known as a natural chemical neurotransmitter and is also a cytotoxic and genotoxic molecule for cell apoptosis. In this work, the interaction of DNA with dopamine was investigated. Though the electrostatic interaction of DNA and dopamine was weak in aqueous solution, dopamine condensed circular pBR322 DNA into toroids on the mica surface cooperatively with ethanol. The formed DNA toroids came from the shrinking of DNA that was driven by ethanol-enhanced DNA-dopamine electrostatic interaction. The size of the DNA toroids could be modulated by varying the concentration of dopamine. This study offers useful information about the DNA condensation induced by monovalent cations and the sample preparation for AFM measurement and application. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Guo CL;Liu ZL;Xu FG;Sun LL;Sun YJ;Yang T;Li Z.Surface-Relevant Regulable DNA Toroids Induced by Dopamine,JOURNAL OF PHYSICAL CHEMISTRY B ,2009,113(17):6068-6073 |
Palavras-Chave | #ATOMIC-FORCE MICROSCOPY #INDUCED APOPTOSIS #MICA #CONDENSATION #NUCLEATION #MOLECULES #LIQUID #CELLS #SIZE |
Tipo |
期刊论文 |