米托蒽醌与双链及三链核酸相互作用的电喷雾质谱研究

The interaction of mitoxantrone (MXT) with duplex and triplex DNA, contain repeating sequence CTCT, CCTT and CTT were studied by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS). The 1:3 specific complexes of mitoxantrone and duplex DNA and 1:2 specific complexes of mitoxantrone and triplex DNA were observed. The results show that mitoxantrone has no remarkable sequence selectivity, however it has distinct structure selectivity, and destabilization the triplex.