Interactions of mitoxantrone with duplex and triplex DNA studied by electrospray ionization mass spectrometry
Data(s) |
2008
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Resumo |
We have examined interactions between mitoxantrone (MXT) and DNA duplexes or triplexes with different base compositions by using electrospray ionization mass spectrometry (ESI-MS), respectively. MXT interacts preferentially with DNA duplexes compared to the triplexes. In the mass spectrum of the duplex-MXT mixture, the complex peaks dominated in the ratios of duplex/MXT of 1:1, 1:2 and 1:3, and the 1:2 duplex/MXT peak was the most abundant. In contrast, only 1:1 triplex-MXT complexes were observed in the mass spectrum of the triplex-MXT mixture, and the most intensive peak was a free triplex ion without MXT. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Wan CH;Guo XH;Song FR;Liu ZQ;Liu SY.Interactions of mitoxantrone with duplex and triplex DNA studied by electrospray ionization mass spectrometry,RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2008,22(24 ):4043-4048 |
Palavras-Chave | #DOUBLE-STRANDED OLIGODEOXYNUCLEOTIDES #NONCOVALENT COMPLEXES #SEQUENCE SPECIFICITY #NUCLEIC-ACIDS #FTICR-MS #ESI-MS #BINDING #LIGANDS #DRUGS #ANTHRAPYRAZOLES |
Tipo |
期刊论文 |