Single-walled carbon nanotubes binding to human telomeric i-motif DNA under molecular-crowding conditions: More water molecules released


Autoria(s): Zhao C; Ren JS; Qu XG
Data(s)

2008

Resumo

The natural occurrence of the human telomeric G-quadruplex or i-motif in vivo has not been demonstrated and the biological effects of the induction of these structures need to be clarified. Intracellular environments are highly crowded with various biomolecules and in vitro studies under molecular-crowding conditions will provide important information on how biomolecules behave in cells. Here we report that cell-mimic crowding can increase i-motif stability at acid pH and cause dehydration.

Identificador

http://ir.ciac.jl.cn/handle/322003/10831

http://www.irgrid.ac.cn/handle/1471x/147658

Idioma(s)

英语

Fonte

Zhao C;Ren JS;Qu XG.Single-walled carbon nanotubes binding to human telomeric i-motif DNA under molecular-crowding conditions: More water molecules released,CHEMISTRY-A EUROPEAN JOURNAL,2008,14(18):5435-5439

Palavras-Chave #G-QUADRUPLEX #HYDRATION CHANGES #EXCLUDED-VOLUME #DUPLEX #TRIPLEX
Tipo

期刊论文