Self-assembly of single-stranded RNA on carbon nanotube: Polyadenylic acid to form a duplex structure
Data(s) |
2008
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Resumo |
All messenger-RNA (mRNA) molecules in eukaryotic cells have a polyadenylic acid [poly (rA)] tail at the 3'-end and human poly (rA) polymerase (PAP) has been considered as a tumor-specific target. A ligand that is capable of recognizing and binding to the poly(M) tail of mRNA might interfere with the full processing of mRNA by PAP and can be a potential therapeutic agent. We report here for the first time that single-walled carbon nanotubes (SWNTs) can cause single-stranded poly (M) to self-structure and form a duplex structure, which is studied by UV melting, atomic force microscopy, circular dichroism spectroscopy, and NMR spectrometry. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Zhao C;Peng YH;Song YJ;Ren JS;Qu XG.Self-assembly of single-stranded RNA on carbon nanotube: Polyadenylic acid to form a duplex structure,SMALL,2008,4(5):656-661 |
Palavras-Chave | #TARGETING RNA #PROCESSING ENZYME #SMALL MOLECULES #DNA #BINDING #COMPLEX #CONDENSATION #RECOGNITION #TRANSITION #DICHROISM |
Tipo |
期刊论文 |