Aliphatic Poly(ester-carbonate)s Bearing Amino Groups and Its RGD Peptide Grafting
Data(s) |
2008
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Resumo |
This article deals with (1) synthesis of novel cyclic carbonate monomer (2-oxo [1,3]dioxan-5-yl)carbamic acid benzyl ester (CAB) containing protected amino groups; (2) ring-opening copolymerization of the cyclic monomer with L-lactide (LA) to provide novel degradable poly(ester-carbonate)s with functional groups; (3) removal of the protective benzyloxycarbonyl (Cbz) groups by catalytic hydrogenation to afford the corresponding poly(ester-co-carbonate)s with free amino groups; (4) grafting of oligopeptide Gly-Arg-Gly-Asp-Ser-Tyr (GRGDSY, abbreviated as RGD) onto the copolymer pendant amino groups in the presence of 1,1'-carbonyldiimidazole (CDI). |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Hu XL;Chen XS;Xie ZG;Cheng HB;Jing XB.Aliphatic Poly(ester-carbonate)s Bearing Amino Groups and Its RGD Peptide Grafting,JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY ,2008,46(21):7022-7032 |
Palavras-Chave | #RING-OPENING POLYMERIZATION #BIODEGRADABLE COPOLYMER #TRIMETHYLENE CARBONATE #POLY(CARBONATE ESTER)S #MULTIBLOCK COPOLYMERS #BLOCK-COPOLYMER #LACTIC-ACID #5-METHYL-5-BENZYLOXYCARBONYL-1 #POLYCARBONATE #GLYCEROL #3-DIOXAN-2-ONE |
Tipo |
期刊论文 |