A Biodegradable Diblcok Copolymer Poly(ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate): Docetaxel and RGD Conjugation
Data(s) |
2008
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Resumo |
A diblcok copolymer monomethoxy poly (ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate) (MPEG-b-P(LA-co-MCC)) was obtained by copolymerization of L-lactide (LA) and 2-methyl-2-benzoxycarbonyl-propylene carbonate (MBC) and subsequent catalytic hydrogenation. The pendant carboxyl groups of the copolymer MPEG-b-P(LA-co-MCC) were conjugated with antitumor drug docetaxel and tripeptide arginine-glycine-aspartic acid (RGD), respectively. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Xie ZG;Hu XL;Chen XS;Lu TC;Liu S;Jing XB.A Biodegradable Diblcok Copolymer Poly(ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate): Docetaxel and RGD Conjugation,JOURNAL OF APPLIED POLYMER SCIENCE,2008,110(5):2961–2970 |
Palavras-Chave | #ACID) TRIBLOCK COPOLYMER #BLOCK-COPOLYMER #CELL-ADHESION #SURFACES #FIBRONECTIN #OSTEOBLASTS |
Tipo |
期刊论文 |