Evaluation of flavonoids binding to DNA duplexes by electrospray ionization mass spectrometry
Data(s) |
2008
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Resumo |
In this study, electrospray ionization mass spectrometry (ESI-MS) was used to investigate the binding interactions of ten flavonoid aglycones and ten flavonoid glycosides with DNA duplexes. Relative binding affinities of the flavonoids toward DNA duplexes were estimated based on the fraction of bound DNA. The results revealed that the 4'-OH group of flavonoid aglycones was essential for their DNA-binding properties. Flavonoid glycosides with sugar chain linked on ring A or ring B showed enhanced binding toward the duplexes over their aglycone counterparts, whereas glycosylation of the flavonol quercetin on ring C exhibited a less pronounced effect. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Wang ZF;Cui M;Song FR;Lu L;Liu ZQ;Liu SY.Evaluation of flavonoids binding to DNA duplexes by electrospray ionization mass spectrometry,JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,2008,19(7):914-922 |
Palavras-Chave | #DOUBLE-STRANDED OLIGODEOXYNUCLEOTIDES #NEGATIVE-ION MODE #NONCOVALENT COMPLEXES #TOPOISOMERASE-I #PROTOBERBERINE ALKALOIDS #G-QUADRUPLEX #AMINO SUGAR #ESI-MS #DRUGS #CLEAVAGE |
Tipo |
期刊论文 |