Efficient synthesis of α-alkylidene-β-lactams via NaOH-promoted intramolecular aza-Michael addition of α-carbamoyl ketene-S,S-acetals in aqueous media
| Data(s) |
2008
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| Resumo |
A facile and efficient synthesis of substituted alpha-alkylidene-beta-lactams have been developed via a NaOH-promoted intramolecular aza-Michael addition of alpha-carbamoyl, alpha-(1-chlorovinyl) ketene-S,S-acetals and subsequent nucleophilic vinylic substitution (SNV) reaction in alcoholic aqueous media. (C) 2008 Elsevier Ltd. All rights reserved. |
| Identificador | |
| Idioma(s) |
英语 |
| Fonte |
Yang Y;Xiang DX;Zhao XL;Liang YJ;Huang J;Dong DW.Efficient synthesis of α-alkylidene-β-lactams via NaOH-promoted intramolecular aza-Michael addition of α-carbamoyl ketene-S,S-acetals in aqueous media ,Tetrahedron,2008,64(22):4959-4966 |
| Palavras-Chave | #aqueous media #2-azetidinone #beta-lactams #Michael addition #vilsmeier reagent |
| Tipo |
期刊论文 |
