Concise synthesis of novel practical sulfamide-amine alcohols for the enantioselective addition of diethylzinc to aldehydes


Autoria(s): Mao, JC; Wan, BS; Wang, RL; Wu, F; Lu, SW
Data(s)

24/12/2004

Resumo

Novel sulfamide-amine alcohol ligands were designed using a grafting strategy and synthesized from readily available starting materials via a simple, efficient method. The key features of these ligands for the asymmetric addition of diethylzinc to aldehydes included stability, enhanced effectiveness without using Ti((OPr)-Pr-i)(4), suitability for a variety of aldehydes, the ability to operate at room temperature, and selectability to afford either absolute configuration products with enantiomeric excess up to >99%.

Identificador

http://159.226.238.44/handle/321008/81891

http://www.irgrid.ac.cn/handle/1471x/137057

Idioma(s)

英语

Fonte

毛金成;万伯顺;王荣良;吴凡;陆世维.Concise Synthesis of Novel Practical Sulfamide-Amine Alcohols for the Enantioselective Addition of Diethylzinc to Aldehydes,Journal of Organic Chemistry,2004,69():9123-9127

Tipo

期刊论文