Hydroxylated metabolites of polychlorinated biphenyls and their endocrine disrupting mechanism


Autoria(s): Yang, FX; Xu, Y
Data(s)

01/07/2005

Resumo

Hydroxylated polychlorinated biphenyls (OH-PCBs a group of main active metabolites of polychlorinated biphenyl (PCBs) which are typical persistent organic pollutants (Pops) I have been identified in wild animals and human. The endocrine disruption of OH-PCBs has been drawn great attention due to the similarity of their chemical structures to the natural estrogens and thyroid hormones. The metabolic pathways of PCBs, the levels of OHPCBs in organism, the endocrine disruption and other adverse effects of OH-PCBs are reviewed. The further investigation of OH-PCBs will not only reveal the toxicological mechanism of PCBs, but also can lay scientific basis for setting up the risk assessment of POPs contamination and early-warning system in China.

Hydroxylated polychlorinated biphenyls (OH-PCBs a group of main active metabolites of polychlorinated biphenyl (PCBs) which are typical persistent organic pollutants (Pops) I have been identified in wild animals and human. The endocrine disruption of OH-PCBs has been drawn great attention due to the similarity of their chemical structures to the natural estrogens and thyroid hormones. The metabolic pathways of PCBs, the levels of OHPCBs in organism, the endocrine disruption and other adverse effects of OH-PCBs are reviewed. The further investigation of OH-PCBs will not only reveal the toxicological mechanism of PCBs, but also can lay scientific basis for setting up the risk assessment of POPs contamination and early-warning system in China.

Identificador

http://ir.ihb.ac.cn/handle/152342/9204

http://www.irgrid.ac.cn/handle/1471x/59115

Idioma(s)

英语

Fonte

Yang, FX; Xu, Y.Hydroxylated metabolites of polychlorinated biphenyls and their endocrine disrupting mechanism,PROGRESS IN CHEMISTRY,2005,17(4):740-748

Palavras-Chave #Chemistry #Multidisciplinary #polychlorinated biphenyls #hydroxylated polychlorinated biphenyls #OH-PCBs #endocrine disruption
Tipo

期刊论文