Median network analysis of defectively sequenced entire mitochondrial genomes from early and contemporary disease studies

Sequence analysis of the mitochondrial genome has become a routine method in the study of mitochondrial diseases. Quite often, the sequencing efforts in the search of pathogenic or disease-associated mutations are affected by technical and interpretive pr

We thank MJ Rieder for transmitting a table with the variant nucleotides for the sequences of his 1998 paper. YGY was supported by the 'Century Program' (or Hundreds-Talent Program) of the Chinese Academy of Sciences.