Alpha-momorcharin inhibits HIV-1 replication in acutely but not chronically infected T-lymphocytes
Data(s) |
1999
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Resumo |
AIM: To identify the anti-human immunodeficiency virus type 1 (HIV-1) activities of alpha-momorcharin ( alpha-MMC) from Momordica charantia in acutely and chronically infected lymphocytes. METHODS: The anti-HIV activities of alpha-MMC were examined by 1) the inhibition of syncytia formation induced by HIV-1 III B; 2) reduction of p24 core antigen expression level and decrease in numbers of HIV antigen positive cells in acutely and chronically infected cultures. The cytotoxic effects of alpha-MMC was tested by trypan blue dye exclusion or colorimetric MTT assay. RESULTS: alpha-MMC was found to obviously inhibit HIV-1 III B-inducing C8166 syncytia formation and markedly reduced both expression of p24 core antigen and the numbers of HIV antigen positive cells in acutely but not chronically HTV-1-infected culture. The median effective concentration (EC50) in these assays were 0.016, 0.07, and 0.32 mg.L-1, respectively. CONCLUSION: alpha-MMC is a unique component of momorcharin with anti-HIV activity, and markedly inhibited HIV-1 replication in acutely but not chronically HIV-1-infected T-lymphocytes. |
Identificador | |
Direitos |
Alpha-momorcharin inhibits HIV-1 replication in acutely but not chronically infected T-lymphocytes |
Fonte |
Zheng, YT; Ben, KL; Jin, SW.Alpha-momorcharin inhibits HIV-1 replication in acutely but not chronically infected T-lymphocytes,20,239-243,(SCI-E ): |
Palavras-Chave | #Chemistry, Multidisciplinary; Pharmacology & Pharmacy |
Tipo |
期刊论文 |