Dibenzocyclooctadiene Lignans from Schisandra lancifolia and Their Anti-human Immunodeficiency Virus-1 Activities

Three new dibenzocyclooctadiene lignans, schilancifolignans A-C (1-3), together with thirteen known ones, were isolated from the leaves and stems of Schisandru lancifolia. The structures of 1-3 were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compounds 1-3 were tested for their anti-human immunodeficiency virus-1 activities and showed weak bioactivities.

We thank Prof. Naihe Jing (Shanghai Institute of Biochemistry and Cell Biology) for the reporter plasmids. This work was supported by grants from the Key State Research Program from the Ministry of Science and Technology of China (2006CB943902 and 2007CB947201), the Innovation Project of Chinese Academy of Sciences (KSCX2-YW-R-090) and the National Natural Science Foundation of China (305303800).