Dibenzocyclooctadiene Lignans from Schisandra wilsoniana and Their Anti-HIV-1 Activities

Twelve new dibenzocyclooctadiene lignans, marlignans A-L (1-12), together with 16 known compounds, were isolated from the leaves and stems of Schisandra wilsoniana. The structures of 1-12 were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques. Compounds 1-12 were evaluated for their anti-HIV activities, of which compounds 3, 6, 8, and 12 showed modest activities with therapeutic index values of 13.2, 15.6, 17.6, and 16.4, respectively.

This work was supported by Chinese National Natural Science Foundation Grants 30830021 and 30900240, Chinese Academy of Sciences Grants KSCXZ-YW-R-088 and KSCX2-YW-G-024, and Ministry of Science Grants 2008AA02Z133, 2008AA101001, and 2010CB529800.