Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors
| Data(s) |
2008
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| Resumo |
Three new types of aryl diketo acid (ADK) isosteres were designed by conversion of the biologically labile 1,3-diketo unit into heteroaromatic motif such as isoxazole, isothiazole, or 1H-pyrazole to improve the physicochemical property of ADK-based HIV-1 National Natural Science Foundation of China (30672528), Science and Technology Commission of Shanghai Municipality (07QH14018), Key Scientific and Technological Projects of China (200413A719A14) and Yunnan province (2004NG12) are greatly appreciated for |
| Identificador | |
| Direitos |
Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors |
| Fonte |
Zeng, LF; Zhang, HS; Wang, YH; Sanchez, T; Zheng, YT; Neamati, N; Long, YQ.Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors,18,4521-4524,(SCI-E ):National Natural Science Foundation of China (30672528), Science and Technology Commission of Shanghai Municipality (07QH14018), Key Scientific and Technological Projects of China (200413A719A14) and Yunnan province (2004NG12) are greatly appreciated for |
| Palavras-Chave | #Chemistry, Medicinal; Chemistry, Organic |
| Tipo |
期刊论文 |
