Symmetrical 1-pyrrolidineacetamide showing anti-HIV activity through a new binding site on HIV-1 integrase

Aim: To characterize the functional and pharmacological features of a symmetrical 1-pyrrolidineacetamide, N,N'-(methylene-di-4,1-phenylene) bis-1-pyrrolidineacetamide, as a new anti-HIV compound which could competitively inhibit HIV-1 integrase (IN) bindi

This work was financially supported by the National Natural Science Foundation of China (No 30525024, 20472095, and 20572023), Shanghai Pujiang Program (No 05PJ14034), Shanghai Key Basic Research Project (No 06JC14080 and 05JC14092), the State Key Program