Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha
Data(s) |
2005
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Resumo |
Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C (1-2), were isolated from Schisandra micrantha; micrandilactone C ( 2) exhibited an EC50 value of 7.71 mu g/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of 2 make it a promising lead for therapeutic development of a new generation of anti-HIV drug. |
Identificador | |
Direitos |
Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha |
Fonte |
Li, RT; Han, QB; Zheng, YT; Wang, RR; Yang, LM; Lu, Y; Sang, SQ; Zheng, QT; Zhao, QS; Sun, HD.Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha,,2936-2938,(SCI-E): |
Palavras-Chave | #Chemistry, Multidisciplinary |
Tipo |
期刊论文 |