Absence of association between SERPINE2 genetic polymorphisms and chronic obstructive pulmonary disease in Han Chinese: a case-control cohort study

Background: Recent studies have proposed that the serine protease inhibitor E2 (SERPINE2) was a novel susceptibility gene for chronic obstructive pulmonary disease (COPD) in Caucasians. However, this issue still remained controversial. Additional evidence

We appreciated Dr. Qing-Peng Kong and Liang Xie's comments. We also thank Ms. Catherine Southard and Ellen Leffler for going through the manuscript. The work was supported by grants from National Natural Science Foundation of China and the Science and Tec