Winter Temperature and UV Are Tightly Linked to Genetic Changes in the p53 Tumor Suppressor Pathway in Eastern Asia
| Data(s) |
2009
|
|---|---|
| Resumo |
The tumor suppressor p53 is a master sensor of stress. Two human-specific polymorphisms, p53 codon 72 and MDM2 SNP309, influence the activities of p53. There is a tight association between cold winter temperature and p53 Arg72 and between low UV intensity We are thankful to people who provided their DNA samples, to Maureen Murphy in the Fox Chase Cancer Center, Philadelphia, PA, who provided the Soas2-ts cells for this study, and to Hua Chen from Harvard Medical School who helped in analyzing the genetic s |
| Identificador | |
| Direitos |
Winter Temperature and UV Are Tightly Linked to Genetic Changes in the p53 Tumor Suppressor Pathway in Eastern Asia |
| Fonte |
Shi, Hong; Tan, Si-jie; Zhong, Hua; Hu, Wenwei; Levine, Arnold; Xiao, Chun-jie; Peng, Yi; Qi, Xue-bin; Shou, Wei-hua; Ma, Run-lin Z.; Li, Yi; Su, Bing; Lu, Xin.Winter Temperature and UV Are Tightly Linked to Genetic Changes in the p53 Tumor Suppressor Pathway in Eastern Asia,84,534-541,(SCI-E ):We are thankful to people who provided their DNA samples, to Maureen Murphy in the Fox Chase Cancer Center, Philadelphia, PA, who provided the Soas2-ts cells for this study, and to Hua Chen from Harvard Medical School who helped in analyzing the genetic s |
| Palavras-Chave | #Genetics & Heredity |
| Tipo |
期刊论文 |
