Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils


Autoria(s): Liu, Y; Yang, S; Lin, AA; Cavalli-Sforza, LL; Su, B
Data(s)

2005

Resumo

Human neutrophils are a type of white blood cell, which forms an early line of defense against bacterial infections. Neutrophils are highly responsive to the chemokine, interleukin-8 (IL-8) due to the abundant distribution of CXCR1, one of the IL-8 receptors on the neutrophil cell surface. As a member of the GPCR family, CXCR1 plays a crucial role in the IL-8 signal transduction pathway in neutrophils. We sequenced the complete coding region of the CXCR1 gene in worldwide human populations and five representative nonhuman primate species. Our results indicate accelerated protein evolution in the human lineage, which was likely caused by Darwinian positive selection. The sliding window analysis and the codon-based neutrality test identified signatures of positive selection at the N-terminal ligand/receptor recognition domain of human CXCR1.

Identificador

http://159.226.149.42/handle/152453/2123

http://www.irgrid.ac.cn/handle/1471x/46462

Direitos

Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils

Fonte

Liu, Y; Yang, S; Lin, AA; Cavalli-Sforza, LL; Su, B.Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils,61,691-696,(SCI-E):

Palavras-Chave #Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity
Tipo

期刊论文