A novel brain partition highlights the modular skeleton shared by structure and function
Data(s) |
14/04/2016
14/04/2016
03/06/2015
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Resumo |
Elucidating the intricate relationship between brain structure and function, both in healthy and pathological conditions, is a key challenge for modern neuroscience. Recent progress in neuroimaging has helped advance our understanding of this important issue, with diffusion images providing information about structural connectivity (SC) and functional magnetic resonance imaging shedding light on resting state functional connectivity (rsFC). Here, we adopt a systems approach, relying on modular hierarchical clustering, to study together SC and rsFC datasets gathered independently from healthy human subjects. Our novel approach allows us to find a common skeleton shared by structure and function from which a new, optimal, brain partition can be extracted. We describe the emerging common structure-function modules (SFMs) in detail and compare them with commonly employed anatomical or functional parcellations. Our results underline the strong correspondence between brain structure and resting-state dynamics as well as the emerging coherent organization of the human brain. |
Identificador |
Scientific Reports 5 2015 : (2015) // Article ID 10532 2045-2322 http://hdl.handle.net/10810/17909 10.1038/srep10532 |
Idioma(s) |
eng |
Publicador |
Nature Publishing Group |
Relação |
http://www.nature.com/articles/srep10532 info:eu-repo/grantAgreement/EC/FP7/284772 |
Direitos |
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
Palavras-Chave | #resting-state networks #small world #human connectome #cerebral-cortex #diffusion MRI #default mode #connectivity #integration #consciousness #schizophrenia |
Tipo |
info:eu-repo/semantics/article |