Do Nutritional Supplements Have a Role in Age Macular Degeneration Prevention?
Data(s) |
05/04/2016
05/04/2016
2014
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Resumo |
Purpose. To review the proposed pathogenic mechanisms of age macular degeneration (AMD), as well as the role of antioxidants (AOX) and omega-3 fatty acids (omega-3) supplements in AMD prevention. Materials and Methods. Current knowledge on the cellular/molecular mechanisms of AMD and the epidemiologic/experimental studies on the effects of AOX and omega-3 were addressed all together with the scientific evidence and the personal opinion of professionals involved in the Retina Group of the OFTARED (Spain). Results. High dietary intakes of omega-3 and macular pigments lutein/zeaxanthin are associated with lower risk of prevalence and incidence in AMD. The Age-Related Eye Disease study (AREDS) showed a beneficial effect of high doses of vitamins C, E, beta-carotene, and zinc/copper in reducing the rate of progression to advanced AMD in patients with intermediate AMD or with one-sided late AMD. The AREDS-2 study has shown that lutein and zeaxanthin may substitute beta-carotene because of its potential relationship with increased lung cancer incidence. Conclusion. Research has proved that elder people with poor diets, especially with low AOX and omega-3 micronutrients intake and subsequently having low plasmatic levels, are more prone to developing AMD. Micronutrient supplementation enhances antioxidant defense and healthy eyes and might prevent/retard/modify AMD. |
Identificador |
Journal of Ophthalmology 2014 : (2014) // Article ID 901686 2090-004X 2090-0058 http://hdl.handle.net/10810/17793 10.1155/2014/901686 |
Idioma(s) |
eng |
Publicador |
Hindawi Publishing |
Relação |
http://www.hindawi.com/journals/joph/2014/901686/abs/ |
Direitos |
© 2014 Maria D. Pinazo-Durán et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. info:eu-repo/semantics/openAccess |
Palavras-Chave | #pigment epithelial-cellls #fatty-acid composition #blue mountains eye #growth-factor VEGF #beaver dam eye #oxidative stress #eicosapentaenoic acid #clinical-trial #beta-carotene #vitamin-E |
Tipo |
info:eu-repo/semantics/article |