Interaction between the 5-HT system and the basal ganglia: functional implication and therapeutic perspective in Parkinson's disease
Data(s) |
02/02/2016
02/02/2016
17/03/2014
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Resumo |
The neurotransmitter serotonin (5-HT) has a multifaceted function in the modulation of information processing through the activation of multiple receptor families, including G-protein-coupled receptor subtypes (5-HT1, 5-HT2, 5-HT4-7) and ligand-gated ion channels (5-HT3). The largest population of serotonergic neurons is located in the midbrain, specifically in the raphe nuclei. Although the medial and dorsal raphe nucleus (DRN) share common projecting areas, in the basal ganglia (BG) nuclei serotonergic innervations come mainly from the DRN. The BG are a highly organized network of subcortical nuclei composed of the striatum (caudate and putamen), subthalamic nucleus (STN), internal and external globus pallidus (or entopeduncular nucleus in rodents, GPi/EP and GPe) and substantia nigra (pars compacta, SNc, and pars reticulata, SNr). The BG are part of the cortico-BG-thalamic circuits, which play a role in many functions like motor control, emotion, and cognition and are critically involved in diseases such as Parkinson's disease (PD). This review provides an overview of serotonergic modulation of the BG at the functional level and a discussion of how this interaction may be relevant to treating PD and the motor complications induced by chronic treatment with L-DOPA. |
Identificador |
Frontiers in Neural Circuits 8 2014 : (2014) // Article ID 21 1662-5110 http://hdl.handle.net/10810/17174 10.3389/fncir.2014.00021 |
Idioma(s) |
eng |
Publicador |
Frontiers Research Foundation |
Relação |
http://journal.frontiersin.org/article/10.3389/fncir.2014.00021/full#h1 |
Direitos |
© 2014 Miguelez, Morera-Herreras, Torrecilla, Ruiz-Ortega and Ugedo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. info:eu-repo/semantics/openAccess |
Palavras-Chave | #5-HT #basal ganglia #electrophysiology #parkinson's disease #L-DOPA induced dyskinesia #dorsal raphe nucleus #nigra pars reticulata #postmorten human brain #rat substantia-nigra #6-hydroxidopamine lesioned rats #serotonin reuptake inhibitors #induced motor complications #receptor messenger-RNA |
Tipo |
info:eu-repo/semantics/article |