Metal-Free Polymethyl Methacrylate (PMMA) Nanoparticles by Enamine "Click" Chemistry at Room Temperature


Autoria(s): Buruaga, Lorea; Pomposo Alonso, José Adolfo
Data(s)

20/02/2014

20/02/2014

01/12/2011

Resumo

"Click" chemistry has become an efficient avenue to unimolecular polymeric nanoparticles through the self-crosslinking of individual polymer chains containing appropriate functional groups. Herein we report the synthesis of ultra-small (7 nm in size) polymethyl methacrylate (PMMA) nanoparticles (NPs) by the "metal-free" cross-linking of PMMA-precursor chains prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization containing beta-ketoester functional groups. Intramolecular collapse was performed by the one-pot reaction of beta-ketoester moieties with alkyl diamines in tetrahydrofurane at r.t. (i.e., by enamine formation). The collapsing process was followed by size exclusion chromatography and by nuclear magnetic resonance spectroscopy. The size of the resulting PMMA-NPs was determined by dynamic light scattering. Enamine "click" chemistry increases the synthetic toolbox for the efficient synthesis of metal-free, ultra-small polymeric NPs.

Identificador

Polymers 3(4) : 1673-1683 (2011)

2073-4360

http://hdl.handle.net/10810/11585

10.3390/polym3041673

Idioma(s)

eng

Publicador

MDPI

Relação

http://www.mdpi.com/2073-4360/3/4/1673

Direitos

© 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

info:eu-repo/semantics/openAccess

Palavras-Chave #enamine "click" chemistry #intramolecular collapse #unimolecular polymeric nanoparticles
Tipo

info:eu-repo/semantics/article