Association analyses of DNA polymorphisms in bovine SREBP-1, LXRα,FADS1 genes with fatty acid composition in Canadian commercial crossbred beef steers
Data(s) |
30/11/2012
30/11/2012
01/03/2013
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Resumo |
Two previously reported DNA polymorphisms of sterol regulatory element binding transcription factor 1 (SREBP1) and liver X receptor alpha (LXRα) and two DNA polymorphisms of fatty acid desaturase 1 (FADS1) were evaluated for associations with fatty acids in brisket adipose tissue of Canadian cross-bred beef steers. The polymorphism of 84 bp insert/deletion in intron 5 of SREBP1 was significantly associated with the concentration of 9c C17:1 (P=0.013). The G>A single nucleotide polymorphism (SNP) in the exon 4 of LXRα gene was associated with the concentration of 9c, 11t C18:2 (P=0.04), sum of conjugated linoleic acids (CLA) (P=0.025) and 11c C20:1(P=0.042). Two DNA polymorphisms in the promoter region of FADS1, deletion/insertion of ->GTG in rs133053720 and SNP A>G in rs42187276, were significantly associated with concentrations of C17:0 iso, C17:0 ai, total branched chain fatty acids (BFA), 12t C18:1, 13t/14t C18:1, 15t C18:1, and 13c C18:1 (P<0.05). Further studies are needed to validate the associations and to delineate the roles of the gene polymorphisms in determining the fatty acid composition in beef tissues. |
Identificador |
Meat science 93(3) : 429-436 (2013) 0309-1740 http://hdl.handle.net/10810/9117 10.1016/j.meatsci.2012.10.006 |
Idioma(s) |
eng |
Publicador |
Elsevier |
Relação |
http://www.sciencedirect.com/science/article/pii/S0309174012003543 http://www.journals.elsevier.com/meat-science/ |
Direitos |
Elsevier info:eu-repo/semantics/openAccess |
Palavras-Chave | #fatty acid #beef #sterol regulatory element binding protein 1 #liver X receptor alpha #fatty acid desaturase 1 #association |
Tipo |
info:eu-repo/semantics/article |