Enzymatic degradation of polycaprolactone-gelatin blend


Autoria(s): Banerjee, Aditi; Chatterjee, Kaushik; Madras, Giridhar
Data(s)

2015

Resumo

Blends of polycaprolactone (PCL), a synthetic polymer and gelatin, natural polymer offer a optimal combination of strength, water wettability and cytocompatibility for use as a resorbable biomaterial. The enzymatic degradation of PCL, gelatin and PCL-gelatin blended films was studied in the presence of lipase (Novozym 435, immobilized) and lysozyme. Novozym 435 degraded the PCL films whereas lysozyme degraded the gelatin. Though Novozym 435 and lysozyme individually could degrade PCL-gelatin blended films, the combination of these enzymes showed the highest degradation of these blended films. Moreover, the enzymatic degradation was much faster when fresh enzymes were added at regular intervals. The changes in physico-chemical properties of polymer films due to degradation were studied by scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry. These results have important implications for designing resorbable biomedical implants.

Formato

application/pdf

Identificador

http://eprints.iisc.ernet.in/53523/1/Mat_Res_Exp_2-4_045303_2015.pdf

Banerjee, Aditi and Chatterjee, Kaushik and Madras, Giridhar (2015) Enzymatic degradation of polycaprolactone-gelatin blend. In: MATERIALS RESEARCH EXPRESS, 2 (4).

Publicador

IOP PUBLISHING LTD

Relação

http://dx.doi.org/10.1088/2053-1591/2/4/045303

http://eprints.iisc.ernet.in/53523/

Palavras-Chave #Chemical Engineering #Materials Engineering (formerly Metallurgy)
Tipo

Journal Article

PeerReviewed