Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage
Data(s) |
2015
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Resumo |
Novel isoselenazoles with high glutathione peroxidase (GPx) and peroxiredoxin (Prx) activities provide remarkable cytoprotection to human cells, mainly by exhibiting antioxidant activities in the presence of cellular thiols. The cytotoxicity of the isoselenazoles is found to be significantly lower than that of ebselen, which is being clinically evaluated by several groups for the treatment of reperfusion injuries and stroke, hearing loss, and bipolar disorder. The compounds reported in this paper have the potential to be used as therapeutic agents for disorders mediated by reactive oxygen species. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/52145/1/Ang_Che_Int_Edi_54-29_8449_2015.pdf Bhowmick, Debasish and Srivastava, Shubhi and D'Silva, Patrick and Mugesh, Govindasamy (2015) Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage. In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54 (29). pp. 8449-8453. |
Publicador |
WILEY-V C H VERLAG GMBH |
Relação |
http://dx.doi.org/10.1002/anie.201502430 http://eprints.iisc.ernet.in/52145/ |
Palavras-Chave | #Biochemistry #Inorganic & Physical Chemistry |
Tipo |
Journal Article PeerReviewed |