Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum
Data(s) |
2015
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Resumo |
The plane of division of granule neuron progenitors (GNPs) was analysed with respect to the pial surface in P0 to P14 cerebellum and the results showed that there was a significant bias towards the plane of cell division being parallel to pial surface across this developmental window. In addition, the distribution of beta-Catenin in anaphase cells was analysed, which showed that there was a significant asymmetry in the distribution of beta-Catenin in dividing GNPs. Further, inhibition of Sonic Hedgehog (Shh) signalling had an effect on plane of cell division. Asymmetric distribution of beta-Catenin was shown to occur towards the source of a localized extracellular cue. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/52061/1/Bio_Ope_4-7_865_2015.pdf Haldipur, Parthiv and Sivaprakasam, Iswariya and Periasamy, Vinod and Govindan, Subashika and Mani, Shyamala (2015) Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum. In: BIOLOGY OPEN, 4 (7). pp. 865-872. |
Publicador |
COMPANY OF BIOLOGISTS LTD |
Relação |
http://dx.doi.org/10.1242/bio.009886 http://eprints.iisc.ernet.in/52061/ |
Palavras-Chave | #Centre for Neuroscience |
Tipo |
Journal Article PeerReviewed |